The Eukaryotic Cell Cycle and Cancer Biology Diagrams The Keystone Symposium on the Cell Cycle and Development brought together biologists with an interest in how cell cycle control is integrated into the ontogenetic program of multicellular organisms, and showcased research using a wide variety of systems from both animals and plants. A clear indicati โฆ A strong connection exists between the cell cycle and mechanisms required for executing cell fate decisions in a wide-range of developmental contexts. Terminal differentiation is often associated with cell cycle exit, whereas cell fate switches are frequently linked to cell cycle transitions in divi โฆ Summary: This Review article discusses how cell fate decisions in development are linked to the cell cycle, and the key molecular components thereof. Introduction. The identity of a cell can be defined by its specific, metastable program of transcription and by the activity of cell type-specific transcription factors.
The intersection between cell cycle control and cell fate determination mechanisms involves developmental signals and cyclin-dependent protein kinases (CDKs) targeting transcription factors that control developmental genes. Cell-autonomous determination of cell-type choice in Dictyostelium development by cell-cycle phase. The cell cycle is driven by the activity of cyclin-dependent kinase (CDK)-cyclin complexes. Therefore, internal and external signals converge on the regulation of CDK-cyclin activity to modulate cell proliferation in specific developmental processes and under various environmental conditions. Perfectly orchestrated periodic gene expression during cell cycle progression is essential for maintaining genome integrity and ensuring that cell proliferation can be stopped by environmental signals. Genetic and proteomic studies during the past two decades revealed remarkable evolutionary conservation of the key mechanisms that control cell cycle-regulated gene expression, including
Cycling through developmental decisions: how cell cycle dynamics ... Biology Diagrams
Here, we have focused on the ways in which molecular mechanisms that control the cell cycle act locally and globally to coordinate development. Developing biochemical sensors of Cdk1 activity in diverse model systems will likely uncover the mechanisms by which embryos coordinate the cell cycle and subsequent physical or morphological events The Keystone Symposium on the Cell Cycle and Development brought together biologists with an interest in how cell cycle control is integrated into the ontogenetic program of multicellular organisms, and showcased research using a wide variety of systems from both animals and plants. A clear indication from the meeting is that this research is changing the conventional wisdom on both cell cycle
The cell cycle is driven by the activity of cyclin-dependent kinase (CDK)-cyclin complexes. Therefore, internal and external signals converge on the regulation of CDK-cyclin activity to modulate cell proliferation in specific developmental processes and under various environmental conditions. CDK-cy โฆ
